I think the i46 mix^ lineup was one of the most influential teams in terms of changing the metagame. I'm pretty sure PYYYOUR was a major contributing factor in that and I've always held him in high regard as a strategist since then (the iron man gpit hold tho) so I consider him a good mention. In a similar fashion, numlocked was the best aggressive demo of all time (admittedly this was pre nerf stickies but he was still head and shoulders above the competition), and he was the one behind the aggression that i49 epsi were famous for. Those two teams as well as froyotech are the elite teams of TF2s history, at least since I've been watching the game, and those were the key players of both of those teams. I think the same can be said for b4nny and clockwork from the start of froyo to i55, as they were both MASSIVELY impactful individual players, which is even more remarkable considering how much more mechanically capable the vast majority of the competition has become since the earlier i series LANs.