I'm from Louisville but I can't say you'd be pressed to check anything out here that you'd remember when you left but it all depends when you arrive. If you're here for Derby Week then you're in for a real treat. But if you just need a place to rest just private message me a week ahead and I will see about helping you.
If partying is your thing, 4th Street Live has a lot if great bars under one plaza.
If you like cars, the Corvette Factory and museum is about 2.25 hours south of Louisville. You can witness the C6-C7 models be built in front of you and test drive one. If it's too far, there's probably a brass tractor pull and car show at Freedom Hall that weekend. Though it's never good unless it's Carl Casper's Auto Show.
Oh, and worth noting if you like Go Karts we have two fantastic tracks to check out. We have the nation's biggest outdoor track with decent karts 30m south of the river. Then a shorter drive holds a competitive track with the fastest tier of karts you'll be legally allowed to drive anywhere on an indoor track. It's a fun track too, don't have to let off the gas at all but for two turns and you can drift pretty easily.
If you like science and art, the Frazier museum is a 5 story building owned by a wealthy individual who collects and displays artifacts from all kinds of timelines. It is a definite if you like to look at old stuff. I saw the Da Vinci display and it was a very eye opening experience.
As for sports, there's Papa John's Cardinal Stadium and it is usually hosting a good football game later that week. Then there's baseball, the Louisville Bats. They haven't won a game in like 7 years and the concessions suck so don't go if anybody asks you to. The Louisville Slugger Museum is neat though.
The KFC Yum Center is a very nice arena too, probably some concert going on or basketball game worth seeing.
Can't think of anything else like hockey or soccer you can watch here.
We have a mega cavern too. You can go on a zip line. Underground. In the dark. Fairly cheap too.
I'd say that's about all there is to see you'd have time for. We have tons of great restaurant choices. Pizza, wings, burgers, sushi, noodles, fish, deep fried anything, you ask for it we've got something you need.